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Tuesday, May 12, 2020 | History

4 edition of The teratogenic effects of exercise and pregnancy outcome in mice found in the catalog.

The teratogenic effects of exercise and pregnancy outcome in mice

The teratogenic effects of exercise and pregnancy outcome in mice

  • 122 Want to read
  • 30 Currently reading

Published .
Written in English

    Subjects:
  • Exercise for women -- Physiological aspects,
  • Pregnancy,
  • Teratogenesis

  • Edition Notes

    Statementby William Henry Boehnke.
    The Physical Object
    FormatMicroform
    Paginationx, 63 leaves
    Number of Pages63
    ID Numbers
    Open LibraryOL13598074M
    OCLC/WorldCa14554262

    Teratogen Information; Teratogen Information. for Health Care Providers. Definition of teratogen: A teratogen is an exposure (substance, organism or process) in pregnancy that has a harmful effect on the fetus. Teratogens can be diseases, medications, drugs and environmental exposures. was related to the effects of phenytoin on ossification during the organogenic on fetuses of mice. This study examined the effect of phenytoin on ossification on mice fetuse during organogenesis. This study showed that the incidence of teratogenic effects of this drug is associated to dose and days that it has been used in pregnancy.

    Tuberculosis (TB) was declared a public health emergency by WHO in The disease is a significant contributor to maternal mortality and is among the three leading causes of death among women aged 15–45 years in high burden areas. The exact incidence of tuberculosis in pregnancy, though not readily available, is expected to be as high as in the general wiztechinplanttraining.com by: Each one has a different effect on the pregnant woman before and after pregnancy. Some of them will also only have an effect on an unborn embryo at certain times during the pregnancy. Teratogens are very hard to predict and even harder to manage which one will cause the most damage.

    Nov 25,  · Available evidence supports the existence of both risks and benefits of aerobic conditioning during human pregnancy. During intensive exertion, maternal skeletal muscle and the fetus may compete for blood flow, oxygen delivery and essential fuel substrates. Hence, the most important hypothetical risks include acute fetal hypoxia, hyperthermia and malnutrition. If exercise is repeated Cited by: Studies in humans have not been done. Gliclazide is not recommended for use during pregnancy. {76}7 No teratogenic effects were found in studies of mice and rabbits. Embryotoxicity was not seen in studies of rats. However, a significant decrease in offspring viability at 48 hours was seen when pregnant females were treated up to delivery.


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The teratogenic effects of exercise and pregnancy outcome in mice Download PDF EPUB FB2

Get this from a library. The teratogenic effects of exercise and pregnancy outcome in mice. [William Henry Boehnke]. Pregnant mice were sacrificed on the 19th day of pregnancy, and the fetuses were recovered.

A positive training effect was demonstrated by a significant increase in succinate dehydrogenase activity in the gastrocnemius muscles of exercising wiztechinplanttraining.com by: 5.

In summary, according to our findings PGB may have potential teratogenic effects even in lower doses though with less intensity than other AEDs. It can affect especially bone skeletal development. It seems that PGB can also increase the risk of miscarriage and decrease in normal pregnancy outcome.

Oct 23,  · The dual stresses of pregnancy and exercise may create conflicting physiological demands that could adversely affect pregnancy outcome.

Specifically, redistribution of uterine blood flow and subsequent fetal hypoxia, hyperthermia and the risk of teratogenic effects, decreased carbohydrate availability for the fetus, and increased uterine contractility with a possible increase in Cited by: Mar 24,  · There are reports of limb and central nervous system defects in mice, marked developmental toxic effects and retardation of skeletal growth in rats, and congenital malformations in rabbits.

However, the animal studies typically use high doses of single solvents and a variety of routes of wiztechinplanttraining.com by: Teratogenic effect of Carbamazepine use during pregnancy in the mice. Pak.

Pharm. Sci., Vol, No.1, Januarypp Fig A photomicrograph of brain tissue of mice in the first day of delivery in the control group shows normal pyramidal cells (P) and glial cells (G).

-contains summaries on the effects of medications, chemicals, infections and physical agents on pregnancy, reproduction and development. This medication was initially introduced in the mid s as a mild sedative to help combat nausea.

It was taken off the market in the s due to unexpected effects on fetuses. The effects depend on the nature of the teratogen, the timing at which the exposure occurs and, most likely, the genetic susceptibility of the mother and/or the fetus.

Teratogenic agents can be environmental chemicals, maternal metabolic factors, drugs, or infections. During the first two weeks of gestation, teratogenic agents usually kill the embryo rather than cause congenital malformations. Major malformations are more common in early embryos than in newborns; however, most severely affected embryos are spontaneously aborted.

The aim of this study was to evaluate the effect of exercise on pregnancy outcome in streptozotocin-induced diabetic Wistar rats (n = 11 animals/group).These animals were randomly assigned to sedentary (G1) and exercised groups, beginning from day 0 (G2) or 7 (G3) to day 20 of wiztechinplanttraining.com by: Teratogens have their greatest impact during the critical period when an organ is emerging or rapidly developing; the effects depend on how much and for how long the fetus is exposed; the genetic makeup of both the unborn baby and the mother influence susceptibility to harmful effects of teratogens; and the quality of the prenatal and postnatal environments can influence the outcome of teratogens.

Prenatal ethanol exposure in mice: Teratogenic effects Dietary Zinc Supplementation Throughout Pregnancy Protects Against Fetal Dysmorphology and Improves Postnatal Survival After Prenatal Ethanol Exposure in Mice, Alcoholism: Clinical and Experimental Research,33, 4.

Pregnant mice were euthanized on GD 17 to 18 to measure various parameters in the dam and the litter. We designed this model to facilitate future explorations of the effects of iron supplementation on iron-deficiency anemia during pregnancy.

Crown–rump length is commonly used to evaluate teratogenic effects on fetal development Cited by: This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects.

It is designed for use as a unique guide to these chemicals in. A Review of the Teratogenic Factors Effect on Embryo of the mothers' relative pregravid body weight to pregnancy outcome. Perinatal mortality rates progressively increased from 37 of in. Teratogens act via a specific mechanism on developing cells and tissues to initiate a cascade of altered developmental events.

Teratogenic effects are dependent on the nature of the teratogen, including chemical properties of the chemical, route of exposure, maternal/fetal bioactivation, placental transport, etc.

Feb 01,  · Women should be informed that most cases of nausea and vomiting in pregnancy will resolve spontaneously within 16 to 20 weeks and that nausea and vomiting are not usually associated with a poor pregnancy outcome.

If a woman requests or would like to consider treatment, the following interventions appear to be effective in reducing symptoms.

The Effects of LSD on Chromosomes, Genetic Mutation, Fetal Development and Malignancy The authors concluded that their investigation failed to demonstrate that LSD is teratogenic for mice and Syrian hamsters.

They interpreted the increased frequency of malformed embryos in some of the experiments as an indication of a potentiating effect of.

Exposure of a conceptus to teratogenic or mutagenic agents can have adverse results depending on the type, dose, and route of exposure and the stage of pregnancy. One tenet of teratology is the “all-or-none” phenomenon, the concept that embryonic exposure before organogenesis results in either no adverse embryonic outcome or in embryonic death.

Review: hyperthermia and Fever during Pregnancy Article · Literature Review in Birth Defects Research Part A Clinical and Molecular Teratology 76(7) · July with Reads. Issues in Research on Fetal Drug Effects. Alcohol is one of a number of chemically diverse compounds currently recognized to be toxic to the developing central nervous system (CNS) of humans.

The neurotoxic properties of these compounds have generally been confirmed in animal studies.is a strong medical reason. Effects of teratogens during this period of developmental often times results in an “all or none effect.” That is, the effect of the teratogen, if it is to have any effect, will be so profound as to cause a spontaneous abortion.

Some examples of teratogens known to cause human confirmation are listed in the table.Alpha-methyldopa (Aldomet) has been widely used for the treatment of chronic hypertension in pregnancy.

Although postural hypotension may occur, no unusual fetal effects have been noted. Hydralazine (Apresoline) also has had widespread use in pregnancy, and no teratogenic effect has been observed.

β-Adrenergic Blocking Agents.